Autophagy controls the kinetics and extent of mitochondrial apoptosis by regulating PUMA levels

Macroautophagy is thought to protect against apoptosis, however underlying mechanisms are poorly understood. We examined how autophagy affects canonical death receptor-induced mitochondrial outer membrane permeabilization (MOMP) and apoptosis. MOMP occurs at variable times in a population of cells a...

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Main Authors: Thorburn, Jacqueline, Andrysik, Zdenek, Staskiewicz, Leah, Gump, Jacob, Maycotte, Paola, Oberst, Andrew, Green, Douglas R., Espinosa, Joaquín M., Thorburn, Andrew
格式: Artigo
語言:Inglês
出版: 2014
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3992854/
https://ncbi.nlm.nih.gov/pubmed/24685133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.02.036
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