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Autophagy controls the kinetics and extent of mitochondrial apoptosis by regulating PUMA levels

Macroautophagy is thought to protect against apoptosis, however underlying mechanisms are poorly understood. We examined how autophagy affects canonical death receptor-induced mitochondrial outer membrane permeabilization (MOMP) and apoptosis. MOMP occurs at variable times in a population of cells a...

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書誌詳細
主要な著者: Thorburn, Jacqueline, Andrysik, Zdenek, Staskiewicz, Leah, Gump, Jacob, Maycotte, Paola, Oberst, Andrew, Green, Douglas R., Espinosa, Joaquín M., Thorburn, Andrew
フォーマット: Artigo
言語:Inglês
出版事項: 2014
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3992854/
https://ncbi.nlm.nih.gov/pubmed/24685133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.02.036
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