Autophagy controls the kinetics and extent of mitochondrial apoptosis by regulating PUMA levels

Macroautophagy is thought to protect against apoptosis, however underlying mechanisms are poorly understood. We examined how autophagy affects canonical death receptor-induced mitochondrial outer membrane permeabilization (MOMP) and apoptosis. MOMP occurs at variable times in a population of cells a...

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Main Authors: Thorburn, Jacqueline, Andrysik, Zdenek, Staskiewicz, Leah, Gump, Jacob, Maycotte, Paola, Oberst, Andrew, Green, Douglas R., Espinosa, Joaquín M., Thorburn, Andrew
Format: Artigo
Jezik:Inglês
Izdano: 2014
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3992854/
https://ncbi.nlm.nih.gov/pubmed/24685133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.02.036
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