Synthesis, Biophysical, and Pharmacological Evaluation of the Melanocortin Agonist AST3-88: Modifications of Peptide Backbone at Trp 7 Position Lead to a Potent, Selective, and Stable Ligand of the Melanocortin 4 Receptor (MC4R)

[Image: see text] The melanocortin-3 (MC3R) and melanocortin-4 (MC4R) receptors are expressed in the brain and are implicated in the regulation of food intake and energy homeostasis. The endogenous agonist ligands for these receptors (α-, β-, γ-MSH and ACTH) are linear peptides with limited receptor...

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Detalhes bibliográficos
Main Authors: Singh, Anamika, Dirain, Marvin L., Wilczynski, Andrzej, Chen, Chi, Gosnell, Blake A., Levine, Allen S., Edison, Arthur S., Haskell-Luevano, Carrie
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4198065/
https://ncbi.nlm.nih.gov/pubmed/25141170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cn5000953
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