MiR-133 promotes cardiac reprogramming by directly repressing Snai1 and silencing fibroblast signatures

Fibroblasts can be directly reprogrammed into cardiomyocyte-like cells (iCMs) by overexpression of cardiac transcription factors or microRNAs. However, induction of functional cardiomyocytes is inefficient, and molecular mechanisms of direct reprogramming remain undefined. Here, we demonstrate that...

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Main Authors: Muraoka, Naoto, Yamakawa, Hiroyuki, Miyamoto, Kazutaka, Sadahiro, Taketaro, Umei, Tomohiko, Isomi, Mari, Nakashima, Hanae, Akiyama, Mizuha, Wada, Rie, Inagawa, Kohei, Nishiyama, Takahiko, Kaneda, Ruri, Fukuda, Toru, Takeda, Shu, Tohyama, Shugo, Hashimoto, Hisayuki, Kawamura, Yoshifumi, Goshima, Naoki, Aeba, Ryo, Yamagishi, Hiroyuki, Fukuda, Keiichi, Ieda, Masaki
Format: Artigo
Language:Inglês
Published: BlackWell Publishing Ltd 2014
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4198052/
https://ncbi.nlm.nih.gov/pubmed/24920580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201387605
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