Msp1/ATAD1 maintains mitochondrial function by facilitating the degradation of mislocalized tail-anchored proteins

The majority of ER-targeted tail-anchored (TA) proteins are inserted into membranes by the Guided Entry of Tail-anchored protein (GET) system. Disruption of this system causes a subset of TA proteins to mislocalize to mitochondria. We show that the AAA+ ATPase Msp1 limits the accumulation of misloca...

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Autores principales: Chen, Yu-Chan, Umanah, George K E, Dephoure, Noah, Andrabi, Shaida A, Gygi, Steven P, Dawson, Ted M, Dawson, Valina L, Rutter, Jared
Formato: Artigo
Lenguaje:Inglês
Publicado: BlackWell Publishing Ltd 2014
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Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4198051/
https://ncbi.nlm.nih.gov/pubmed/24843043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201487943
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