Estrogen Receptor Inhibits Mineralocorticoid Receptor Transcriptional Regulatory Function

The steroid hormone aldosterone (aldo) contributes to cardiovascular disease in animal models and in humans. Aldo activates the mineralocorticoid receptor (MR), a hormone-activated transcription factor, and indeed, pharmacological MR inhibition improves cardiovascular outcomes. Because the incidence...

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Autori principali: Barrett Mueller, Katelee, Lu, Qing, Mohammad, Najwa N., Luu, Victor, McCurley, Amy, Williams, Gordon H., Adler, Gail K., Karas, Richard H., Jaffe, Iris Z.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Endocrine Society 2014
Soggetti:
Renal-Cardiac-Vascular
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4197987/
https://ncbi.nlm.nih.gov/pubmed/25051445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2014-1270
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