CDK9-mediated transcription elongation is required for MYC addiction in hepatocellular carcinoma

One-year survival rates for newly diagnosed hepatocellular carcinoma (HCC) are <50%, and unresectable HCC carries a dismal prognosis owing to its aggressiveness and the undruggable nature of its main genetic drivers. By screening a custom library of shRNAs directed toward known drug targets in a...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Huang, Chun-Hao, Lujambio, Amaia, Zuber, Johannes, Tschaharganeh, Darjus F., Doran, Michael G., Evans, Michael J., Kitzing, Thomas, Zhu, Nan, de Stanchina, Elisa, Sawyers, Charles L., Armstrong, Scott A., Lewis, Jason S., Sherr, Charles J., Lowe, Scott W.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Cold Spring Harbor Laboratory Press 2014
Gaiak:
Research Paper
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4197965/
https://ncbi.nlm.nih.gov/pubmed/25128497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.244368.114
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