HLA reduces KIR expression level and frequency in a humanized mouse model

Many human Natural Killer (NK) cells are prevented from killing autologous cells by virtue of inhibitory Killer cell Immunoglobulin-like Receptors (KIR) binding `self' HLA class I molecules. Individual NK cells stably express a selected set of KIR, but it is currently disputed whether the fract...

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Bibliografiska uppgifter
Huvudupphovsmän: van Bergen, Jeroen, Thompson, Allan, Retière, Christelle, van Pel, Melissa, Salvatori, Daniela, Lemonnier, François, Raulet, David, Trowsdale, John, Koning, Frits
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2013
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4197943/
https://ncbi.nlm.nih.gov/pubmed/23390293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1200650
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