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HLA reduces KIR expression level and frequency in a humanized mouse model
Many human Natural Killer (NK) cells are prevented from killing autologous cells by virtue of inhibitory Killer cell Immunoglobulin-like Receptors (KIR) binding `self' HLA class I molecules. Individual NK cells stably express a selected set of KIR, but it is currently disputed whether the fract...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4197943/ https://ncbi.nlm.nih.gov/pubmed/23390293 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1200650 |
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