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Efficient loading of HLA-DR with a T helper epitope by genetic exchange of CLIP

The HLA class II-associated invariant chain (Ii)-derived peptide (CLIP) occupies the peptide binding groove during assembly in the endoplasmic reticulum, travels with HLA class II to endosomal compartments, and is subsequently released to allow binding of antigenic peptides. We investigated whether...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: van Bergen, Jeroen, Schoenberger, Stephen P., Verreck, Frank, Amons, Reinout, Offringa, Rienk, Koning, Frits
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1997
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC23850/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9207120/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.14.7499
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