Efficient transduction and optogenetic stimulation of retinal bipolar cells by a synthetic adeno-associated virus capsid and promoter

In this report, we describe the development of a modified adeno-associated virus (AAV) capsid and promoter for transduction of retinal ON-bipolar cells. The bipolar cells, which are post-synaptic to the photoreceptors, are important retinal targets for both basic and preclinical research. In particu...

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Hlavní autoři: Cronin, Therese, Vandenberghe, Luk H, Hantz, Péter, Juttner, Josephine, Reimann, Andreas, Kacsó, Ágota–Enikő, Huckfeldt, Rachel M, Busskamp, Volker, Kohler, Hubertus, Lagali, Pamela S, Roska, Botond, Bennett, Jean
Médium: Artigo
Jazyk:Inglês
Vydáno: Blackwell Publishing Ltd 2014
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Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4197864/
https://ncbi.nlm.nih.gov/pubmed/25092770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201404077
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