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Diverse strategies targeting alpha7 homomeric and alpha6beta2* heteromeric nicotinic acetylcholine receptors for smoking cessation

Preclinical studies suggest that a diversity of nicotinic acetylcholine receptors (nAChRs) with different sensitivities to nicotine may contribute to tobacco addiction. Using rodent intravenous nicotine self-administration as a preclinical model with good predictive validity for therapeutic efficacy...

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Bibliographic Details
Main Authors: Brunzell, Darlene H., McIntosh, J. Michael, Papke, Roger L.
Format: Artigo
Language:Inglês
Published: 2014
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4197117/
https://ncbi.nlm.nih.gov/pubmed/24730978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/nyas.12421
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