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The role of biotin and oxamate in the carboxyl transferase reaction of pyruvate carboxylase
Pyruvate carboxylase (PC) is a biotin-dependent enzyme that catalyzes the MgATP-dependent carboxylation of pyruvate to oxaloacetate, an important anaplerotic reaction in central metabolism. During catalysis, carboxybiotin is translocated to the carboxyltransferase domain where the carboxyl group is...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4197081/ https://ncbi.nlm.nih.gov/pubmed/25157442 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2014.08.008 |
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