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Pluronic modified leptin with increased systemic circulation, brain uptake and efficacy for treatment of obesity()
Modification of hydrophilic proteins with amphiphilic block copolymers capable of crossing cell membranes is a new strategy to improve protein delivery to the brain. Leptin, a candidate for the treatment of epidemic obesity, has failed in part because of impairment in its transport across the blood–...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4197010/ https://ncbi.nlm.nih.gov/pubmed/24881856 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2014.05.044 |
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