Transport activity and presence of ClC-7/Ostm1 complex account for different cellular functions

Loss of the lysosomal ClC-7/Ostm1 2Cl(−)/H(+) exchanger causes lysosomal storage disease and osteopetrosis in humans and additionally changes fur colour in mice. Its conversion into a Cl(−) conductance in Clcn7(unc/unc) mice entails similarly severe lysosomal storage, but less severe osteopetrosis a...

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Detalhes bibliográficos
Main Authors: Weinert, Stefanie, Jabs, Sabrina, Hohensee, Svea, Chan, Wing Lee, Kornak, Uwe, Jentsch, Thomas J
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2014
Assuntos:
Scientific Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4196982/
https://ncbi.nlm.nih.gov/pubmed/24820037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201438553
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