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Loss of Apc heterozygosity and abnormal tissue building in nascent intestinal polyps in mice carrying a truncated Apc gene.

Mutations in the APC (adenomatous polyposis coli) gene appear to be responsible for not only familial adenomatous polyposis but also many sporadic cases of gastrointestinal cancers. Using homologous recombination in mouse embryonic stem cells, we constructed mice that contained a mutant gene encodin...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Oshima, M, Oshima, H, Kitagawa, K, Kobayashi, M, Itakura, C, Taketo, M
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1995
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC41968/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7753829/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.10.4482
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