Constitutive association of the proapoptotic protein Bim with Bcl-2-related proteins on mitochondria in T cells

Apoptosis in activated T cells in vivo requires the proapoptotic Bcl-2 family member Bim. We show here that, despite its ability to bind LC8, a component of the microtubule dynein motor complex, most of the Bim in both healthy and apoptotic T cells is associated with mitochondria, not microtubules....

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Εκδόθηκε σε:	Proc Natl Acad Sci U S A
Κύριοι συγγραφείς:	Zhu, Yanan, Swanson, Bradley J., Wang, Michael, Hildeman, David A., Schaefer, Brian C., Liu, Xinqi, Suzuki, Hiroyuki, Mihara, Katsuyoshi, Kappler, John, Marrack, Philippa
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	National Academy of Sciences 2004
Θέματα:	Biological Sciences
Διαθέσιμο Online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC419666/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15136728/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0402293101
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