DLBCL Cells with Acquired Resistance to Venetoclax Are Not Sensitized to BIRD-2 But Can Be Resensitized to Venetoclax through Bcl-XL Inhibition

Anti-apoptotic Bcl-2-family members are frequently dysregulated in both blood and solid cancers, contributing to their survival despite ongoing oncogenic stress. Yet, such cancer cells often are highly dependent on Bcl-2 for their survival, a feature that is exploited by so-called BH3-mimetic drugs....

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Principais autores:	Martijn Kerkhofs, Tamara Vervloessem, Kinga B. Stopa, Victoria M. Smith, Meike Vogler, Geert Bultynck
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2020-07-01
Colecção:	Biomolecules
Assuntos:	Ca<sup>2+</sup> signaling ABT-199 BH3 mimetics Bcl-2 Bcl-XL IP<sub>3</sub> receptors
Acesso em linha:	https://www.mdpi.com/2218-273X/10/7/1081
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