Secreted frizzled related proteins inhibit fibrosis in vitro but appear redundant in vivo

BACKGROUND: The pathogenesis of pulmonary fibrosis remains poorly understood. The Wnt signaling pathway regulates fibrogenesis in different organs. Here, we studied the role of two extracellular Wnt antagonists, secreted frizzled-related protein-1 (SFRP1) and frizzled-related protein (FRZB) on lung...

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Bibliografiske detaljer
Main Authors: De Langhe, Ellen, Aznar-Lopez, Carolina, De Vooght, Vanessa, Vanoirbeek, Jeroen A, Luyten, Frank P, Lories, Rik JU
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2014
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4196208/
https://ncbi.nlm.nih.gov/pubmed/25317206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1755-1536-7-14
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