Enhanced endogenous bone morphogenetic protein signaling protects against bleomycin induced pulmonary fibrosis

BACKGROUND: Effective treatments for fibrotic diseases such as idiopathic pulmonary fibrosis are largely lacking. Transforming growth factor beta (TGFβ) plays a central role in the pathophysiology of fibrosis. We hypothesized that bone morphogenetic proteins (BMP), another family within the TGFβ sup...

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Detalhes bibliográficos
Publicado no:Respir Res
Main Authors: De Langhe, Ellen, Cailotto, Frederic, De Vooght, Vanessa, Aznar-Lopez, Carolina, Vanoirbeek, Jeroen Alfons, Luyten, Frank Prosper, Lories, Rik Jozef Urbain
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4364322/
https://ncbi.nlm.nih.gov/pubmed/25849157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12931-015-0202-x
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