Epigenetic regulations in the IFNγ signalling pathway: IFNγ-mediated MHC class I upregulation on tumour cells is associated with DNA demethylation of antigen-presenting machinery genes

Downregulation of MHC class I expression on tumour cells, a common mechanism by which tumour cells can escape from specific immune responses, can be associated with coordinated silencing of antigen-presenting machinery genes. The expression of these genes can be restored by IFNγ. In this study we do...

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Autori principali: Vlková, Veronika, Štěpánek, Ivan, Hrušková, Veronika, Šenigl, Filip, Mayerová, Veronika, Šrámek, Martin, Šímová, Jana, Bieblová, Jana, Indrová, Marie, Hejhal, Tomáš, Dérian, Nicolas, Klatzmann, David, Six, Adrien, Reiniš, Milan
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2014
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4196173/
https://ncbi.nlm.nih.gov/pubmed/25071011
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