IL1RAPL1 knockout mice show spine density decrease, learning deficiency, hyperactivity and reduced anxiety-like behaviours

IL-1 receptor accessory protein-like 1 (IL1RAPL1) is responsible for nonsyndromic intellectual disability and is associated with autism. IL1RAPL1 mediates excitatory synapse formation through trans-synaptic interaction with PTPδ. Here, we showed that the spine density of cortical neurons was signifi...

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Hauptverfasser: Yasumura, Misato, Yoshida, Tomoyuki, Yamazaki, Maya, Abe, Manabu, Natsume, Rie, Kanno, Kouta, Uemura, Takeshi, Takao, Keizo, Sakimura, Kenji, Kikusui, Takefumi, Miyakawa, Tsuyoshi, Mishina, Masayoshi
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4196104/
https://ncbi.nlm.nih.gov/pubmed/25312502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep06613
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