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GluD1 knockout mice with a pure C57BL/6N background show impaired fear memory, social interaction, and enhanced depressive-like behavior

The GluD1 gene is associated with susceptibility for schizophrenia, autism, depression, and bipolar disorder. However, the function of GluD1 and how it is involved in these conditions remain elusive. In this study, we generated a Grid1 gene-knockout (GluD1-KO) mouse line with a pure C57BL/6N genetic...

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Bibliografske podrobnosti
izdano v:PLoS One
Main Authors: Nakamoto, Chihiro, Kawamura, Meiko, Nakatsukasa, Ena, Natsume, Rie, Takao, Keizo, Watanabe, Masahiko, Abe, Manabu, Takeuchi, Tomonori, Sakimura, Kenji
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2020
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7032715/
https://ncbi.nlm.nih.gov/pubmed/32078638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0229288
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