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Dominant-negative action of the jimpy mutation in mice complemented with an autosomal transgene for myelin proteolipid protein.

Mutations in genes encoding membrane proteins have been associated with cell death of unknown cause from invertebrate development to human degenerative diseases. A point mutation in the gene for myelin proteolipid protein (PLP) underlies oligodendrocyte death and dysmyelination in jimpy mice, an acc...

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Sonraí Bibleagrafaíochta
Main Authors: Schneider, A M, Griffiths, I R, Readhead, C, Nave, K A
Formáid: Artigo
Teanga:Inglês
Foilsithe: 1995
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC41961/
https://ncbi.nlm.nih.gov/pubmed/7538670
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