P2X7 Receptor Modulates Inflammatory and Functional Pulmonary Changes Induced by Silica

Silicosis is an occupational lung disease, characterized by irreversible and progressive fibrosis. Silica exposure leads to intense lung inflammation, reactive oxygen production, and extracellular ATP (eATP) release by macrophages. The P2X7 purinergic receptor is thought to be an important immunomod...

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Autori principali: Monção-Ribeiro, Leonardo C., Faffe, Débora S., Santana, Patrícia T., Vieira, Flávia S., da Graça, Carolyne Lalucha A. L., Marques-da-Silva, Camila, Machado, Mariana N., Caruso-Neves, Celso, Zin, Walter A., Borojevic, Radovan, Takiya, Christina M., Coutinho-Silva, Robson
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2014
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4195726/
https://ncbi.nlm.nih.gov/pubmed/25310682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0110185
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