Confirmation of Childhood Acute Lymphoblastic Leukemia Variants, ARID5B and IKZF1, and Interaction with Parental Environmental Exposures

Genome wide association studies (GWAS) have established association of ARID5B and IKZF1 variants with childhood acute lymphoblastic leukemia (ALL). Epidemiological studies suggest that environmental factors alone appear to make a relatively minor contribution to disease risk. The polygenic nature of...

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Autori principali: Evans, Tiffany-Jane, Milne, Elizabeth, Anderson, Denise, de Klerk, Nicholas H., Jamieson, Sarra E., Talseth-Palmer, Bente A., Bowden, Nikola A., Holliday, Elizabeth G., Rudant, Jérémie, Orsi, Laurent, Richardson, Ebony, Lavis, Laura, Catchpoole, Daniel, Attia, John R., Armstrong, Bruce K., Clavel, Jacqueline, Scott, Rodney J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2014
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4195717/
https://ncbi.nlm.nih.gov/pubmed/25310577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0110255
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