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The structure of a yeast RNA-editing deaminase provides insight into the fold and function of activation-induced deaminase and APOBEC-1

Activation-induced deaminase (AID) uses base deamination for class-switch recombination and somatic hypermutation and is related to the mammalian RNA-editing enzyme apolipoprotein B editing catalytic subunit 1 (APOBEC-1). CDD1 is a yeast ortholog of APOBEC-1 that exhibits cytidine deaminase and RNA-...

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Autores principales: Xie, Kefang, Sowden, Mark P., Dance, Geoffrey S. C., Torelli, Andrew T., Smith, Harold C., Wedekind, Joseph E.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2004
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC419566/
https://ncbi.nlm.nih.gov/pubmed/15148397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0400493101
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