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Cytomegalovirus cell death suppressor vMIA blocks Bax- but not Bak-mediated apoptosis by binding and sequestering Bax at mitochondria

We report that the cytomegalovirus-encoded cell death suppressor vMIA binds Bax and prevents Bax-mediated mitochondrial membrane permeabilization by sequestering Bax at mitochondria in the form of a vMIA–Bax complex. vMIA mutants with a defective mitochondria-targeting domain retain their Bax-bindin...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Arnoult, Damien, Bartle, Laura M., Skaletskaya, Anna, Poncet, Delphine, Zamzami, Naoufal, Park, Peter U., Sharpe, Juanita, Youle, Richard J., Goldmacher, Victor S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2004
Schlagworte:
Biological Sciences
Online-Zugang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC419544/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15148411/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0401897101
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