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Geometry and symmetry presculpt the free-energy landscape of proteins
We present a simple physical model that demonstrates that the native-state folds of proteins can emerge on the basis of considerations of geometry and symmetry. We show that the inherent anisotropy of a chain molecule, the geometrical and energetic constraints placed by the hydrogen bonds and steric...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2004
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC419539/ https://ncbi.nlm.nih.gov/pubmed/15148372 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0402525101 |
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