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Deciphering the folding kinetics of transmembrane helical proteins

Nearly a quarter of genomic sequences and almost half of all receptors that are likely to be targets for drug design are integral membrane proteins. Understanding the detailed mechanisms of the folding of membrane proteins is a largely unsolved, key problem in structural biology. Here, we introduce...

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Main Authors: Orlandini, Enzo, Seno, Flavio, Banavar, Jayanth R., Laio, Alessandro, Maritan, Amos
Format: Artigo
Jezik:Inglês
Izdano: The National Academy of Sciences 2000
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC18900/
https://ncbi.nlm.nih.gov/pubmed/11121029
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