Early life stress and serotonin transporter gene variation interact to affect the transcription of the glucocorticoid and mineralocorticoid receptors, and the co-chaperone FKBP5, in the adult rat brain

The short allelic variant of the serotonin transporter (5-HTT) promoter-linked polymorphic region (5-HTTLPR) has been associated with the etiology of major depression by interaction with early life stress (ELS). A frequently observed endophenotype in depression is the abnormal regulation of levels o...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: van der Doelen, Rick H. A., Calabrese, Francesca, Guidotti, Gianluigi, Geenen, Bram, Riva, Marco A., Kozicz, Tamás, Homberg, Judith R.
Format: Artigo
Langue:Inglês
Publié: Frontiers Media S.A. 2014
Sujets:
Neuroscience
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4195371/
https://ncbi.nlm.nih.gov/pubmed/25352794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnbeh.2014.00355
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