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Role of Polo-like kinase in the degradation of early mitotic inhibitor 1, a regulator of the anaphase promoting complex/cyclosome

Early mitotic inhibitor 1 (Emi1) inhibits the activity of the anaphase promoting complex/cyclosome (APC/C), which is a multisubunit ubiquitin ligase that targets mitotic regulators for degradation in exit from mitosis. Levels of Emi1 oscillate in the cell cycle: it accumulates in the S phase and is...

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Main Authors: Moshe, Yakir, Boulaire, Jérôme, Pagano, Michele, Hershko, Avram
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2004
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC419535/
https://ncbi.nlm.nih.gov/pubmed/15148369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0402442101
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