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Mapping quantitative traits with random and with ascertained sibships

Use of a robust score statistic based on a variance components model to map quantitative trait loci in randomly sampled pedigrees is reviewed. Sibships ascertained through a single proband are discussed. Under a standard assumption of multivariate normality, two suggested methods of ascertainment co...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Peng, Jie, Siegmund, D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2004
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Online-Zugang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC419519/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15084737/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0401713101
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