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CD28 ligation induces transplantation tolerance by IFN-γ–dependent depletion of T cells that recognize alloantigens
Administration of an agonistic anti-CD28 mAb paradoxically inhibits donor T cell expansion and prevents graft-versus-host disease (GVHD) in mice. Here we examined the mechanism of anti-CD28–mediated immunosuppression and found that anti-CD28 mAb activated, rather than blocked, CD28-mediated signalin...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
2004
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC419490/ https://ncbi.nlm.nih.gov/pubmed/15173889 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200420940 |
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