ETV6/RUNX1 abrogates mitotic checkpoint function and targets its key player MAD2L1

Approximately 25% of childhood B-cell precursor acute lymphoblastic leukemia have an ETV6/RUNX1 (E/R) gene fusion that results from a t(12;21). This genetic subgroup of leukemia is associated with near-triploidy, near-tetraploidy, and trisomy 21 as rather specific types of secondary changes. Here, w...

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Détails bibliographiques
Auteurs principaux: Krapf, G, Kaindl, U, Kilbey, A, Fuka, G, Inthal, A, Joas, R, Mann, G, Neil, JC, Haas, OA, Panzer-Grümayer, ER
Format: Artigo
Langue:Inglês
Publié: 2010
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4194424/
https://ncbi.nlm.nih.gov/pubmed/20190817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2010.53
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