Blocking ETV6/RUNX1-induced MDM2 overexpression by Nutlin-3 reactivates p53 signaling in childhood leukemia

ETV6/RUNX1 (E/R) is the most common fusion gene in childhood acute lymphoblastic leukemia. It is responsible for the initiation of leukemia but also indispensable for disease maintenance and propagation, although its function in these latter processes is less clear. We therefore investigated the eff...

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Главные авторы: Kaindl, U, Morak, M, Portsmouth, C, Mecklenbräuker, A, Kauer, M, Zeginigg, M, Attarbaschi, A, Haas, O A, Panzer-Grümayer, R
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group 2014
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Original Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3948158/
https://ncbi.nlm.nih.gov/pubmed/24240203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2013.345
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