Blocking ETV6/RUNX1-induced MDM2 overexpression by Nutlin-3 reactivates p53 signaling in childhood leukemia

ETV6/RUNX1 (E/R) is the most common fusion gene in childhood acute lymphoblastic leukemia. It is responsible for the initiation of leukemia but also indispensable for disease maintenance and propagation, although its function in these latter processes is less clear. We therefore investigated the eff...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
Main Authors: Kaindl, U, Morak, M, Portsmouth, C, Mecklenbräuker, A, Kauer, M, Zeginigg, M, Attarbaschi, A, Haas, O A, Panzer-Grümayer, R
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2014
Teme:
Original Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3948158/
https://ncbi.nlm.nih.gov/pubmed/24240203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2013.345
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki