DNA binding and antigene activity of a daunomycin-conjugated triplex-forming oligonucleotide targeting the P2 promoter of the human c-myc gene

Triplex-forming oligonucleotides (TFO) that bind DNA in a sequence-specific manner might be used as selective repressors of gene expression and gene-targeted therapeutics. However, many factors, including instability of triple helical complexes in cells, limit the efficacy of this approach. In the p...

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Hauptverfasser: Carbone, Giuseppina M., McGuffie, Eileen, Napoli, Sara, Flanagan, Courtney E., Dembech, Chiara, Negri, Umberto, Arcamone, Federico, Capobianco, Massimo L., Catapano, Carlo V.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2004
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC419437/
https://ncbi.nlm.nih.gov/pubmed/15121897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkh527
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