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Chemokine CXCL1 enhances inflammatory pain and increases NMDA receptor activity and COX-2 expression in spinal cord neurons via activation of CXCR2

Recent studies have shown that CXCL1 upregulation in spinal astrocytes is involved in the maintenance of neuropathic pain. However, whether and how CXCL1 regulates inflammatory pain remains unknown. Here we show that intraplantar injection of CFA increased mRNA and protein expressions of CXCL1 and i...

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Hlavní autoři: Cao, De-Li, Zhang, Zhi-Jun, Xie, Rou-Gang, Jiang, Bao-Chun, Ji, Ru-Rong, Gao, Yong-Jing
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4194227/
https://ncbi.nlm.nih.gov/pubmed/24852102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.expneurol.2014.05.014
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