CEACAM2 negatively regulates hemi (ITAM-bearing) GPVI and CLEC-2 pathways and thrombus growth in vitro and in vivo

Carcinoembryonic antigen–related cell adhesion molecule-2 (CEACAM2) is a cell-surface glycoprotein expressed on blood, epithelial, and vascular cells. CEACAM2 possesses adhesive and signaling properties mediated by immunoreceptor tyrosine-based inhibitory motifs. In this study, we demonstrate that C...

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Hauptverfasser: Alshahrani, Musaed M., Yang, Eunice, Yip, Jana, Ghanem, Simona S., Abdallah, Simon L., deAngelis, Anthony M., O’Malley, Cindy J., Moheimani, Fatemeh, Najjar, Sonia M., Jackson, Denise E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2014
Schlagworte:
Platelets and Thrombopoiesis
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4192753/
https://ncbi.nlm.nih.gov/pubmed/25085348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-04-569707
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