3,6,2′,4′,5′-Pentahydroxyflavone, an Orally Bioavailable Multiple Protein Kinase Inhibitor, Overcomes Gefitinib Resistance in Non-small Cell Lung Cancer

Non-small cell lung cancer (NSCLC) is the most lethal cancer, causing more than 150,000 deaths in the United States in 2013. The receptor tyrosine kinase inhibitors such as gefitinib are not perfect clinical therapeutic agents for NSCLC treatment due to primary or acquired tyrosine kinase inhibitor...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Sheng, Yuqiao, Li, Wei, Zhu, Feng, Liu, Kangdong, Chen, Hanyong, Yao, Ke, Reddy, Kanamata, Lim, Do Young, Oi, Naomi, Li, Haitao, Peng, Cong, Ma, Wei-Ya, Bode, Ann M., Dong, Ziming, Dong, Zigang
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: American Society for Biochemistry and Molecular Biology 2014
Θέματα:
Signal Transduction
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4192475/
https://ncbi.nlm.nih.gov/pubmed/25122774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.593475
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