3,6,2′,4′,5′-Pentahydroxyflavone, an Orally Bioavailable Multiple Protein Kinase Inhibitor, Overcomes Gefitinib Resistance in Non-small Cell Lung Cancer

Non-small cell lung cancer (NSCLC) is the most lethal cancer, causing more than 150,000 deaths in the United States in 2013. The receptor tyrosine kinase inhibitors such as gefitinib are not perfect clinical therapeutic agents for NSCLC treatment due to primary or acquired tyrosine kinase inhibitor...

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Detalhes bibliográficos
Main Authors: Sheng, Yuqiao, Li, Wei, Zhu, Feng, Liu, Kangdong, Chen, Hanyong, Yao, Ke, Reddy, Kanamata, Lim, Do Young, Oi, Naomi, Li, Haitao, Peng, Cong, Ma, Wei-Ya, Bode, Ann M., Dong, Ziming, Dong, Zigang
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4192475/
https://ncbi.nlm.nih.gov/pubmed/25122774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.593475
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