Losmapimod Overcomes Gefitinib Resistance in Non-small Cell Lung Cancer by Preventing Tetraploidization

The epidermal growth factor receptor (EGFR) is known to play a critical role in non-small cell lung cancer (NSCLC). Constitutively active EGFR mutations, including in-frame deletion in exon 19 and L858R point mutation in exon 21, contribute about 90% of all EGFR-activating mutations in NSCLC. Althou...

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Vydáno v:EBioMedicine
Hlavní autoři: Yeung, Yiu To, Yin, Shuying, Lu, Bingbing, Fan, Suyu, Yang, Ran, Bai, Ruihua, Zhang, Chengjuan, Bode, Ann M., Liu, Kangdong, Dong, Zigang
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2018
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5835564/
https://ncbi.nlm.nih.gov/pubmed/29398601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2018.01.017
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