Anaplerotic Triheptanoin Diet Enhances Mitochondrial Substrate Use to Remodel the Metabolome and Improve Lifespan, Motor Function, and Sociability in MeCP2-Null Mice

Rett syndrome (RTT) is an autism spectrum disorder (ASD) caused by mutations in the X-linked MECP2 gene that encodes methyl-CpG binding protein 2 (MeCP2). Symptoms range in severity and include psychomotor disabilities, seizures, ataxia, and intellectual disability. Symptom onset is between 6-18 mon...

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Detalhes bibliográficos
Main Authors: Park, Min Jung, Aja, Susan, Li, Qun, Degano, Alicia L., Penati, Judith, Zhuo, Justin, Roe, Charles R., Ronnett, Gabriele V.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4192301/
https://ncbi.nlm.nih.gov/pubmed/25299635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0109527
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