Bioenergetic markers in skin fibroblasts of sporadic ALS and PLS patients

Energy metabolism could influence ALS and PLS pathogenesis and the response to therapy. We developed a novel assay to simultaneously assess mitochondrial content and membrane potential in patients’ skin fibroblasts. In ALS and PLS fibroblasts, membrane potential was increased and mitochondrial conte...

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Main Authors: Kirk, Kathryne, Gennings, Chris, Hupf, Jonathan C., Tadesse, Saba, D’Aurelio, Marilena, Kawamata, Hibiki, Valsecchi, Federica, Mitsumoto, Hiroshi, Manfredi, Giovanni
Format: Artigo
Jezik:Inglês
Izdano: 2014
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4192005/
https://ncbi.nlm.nih.gov/pubmed/25090982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ana.24244
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