Rewiring of glutamine metabolism is a bioenergetic adaptation of human cells with mitochondrial DNA mutations

Using molecular, biochemical, and untargeted stable isotope tracing approaches, we identify a previously unappreciated glutamine-derived α-ketoglutarate (αKG) energy-generating anaplerotic flux to be critical in mitochondrial DNA (mtDNA) mutant cells that harbor human disease-associated oxidative ph...

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Библиографические подробности
Опубликовано в: :Cell Metab
Главные авторы: Chen, Qiuying, Kirk, Kathryne, Shurubor, Yevgeniya I., Zhao, Dazhi, Arreguin, Andrea J., Shahi, Ifrah, Valsecchi, Federica, Primiano, Guido, Calder, Elizabeth L., Carelli, Valerio, Denton, Travis T., Beal, Flint M., Gross, Steven S., Manfredi, Giovanni, D’Aurelio, Marilena
Формат: Artigo
Язык:Inglês
Опубликовано: 2018
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5932217/
https://ncbi.nlm.nih.gov/pubmed/29657030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2018.03.002
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