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Rewiring of glutamine metabolism is a bioenergetic adaptation of human cells with mitochondrial DNA mutations
Using molecular, biochemical, and untargeted stable isotope tracing approaches, we identify a previously unappreciated glutamine-derived α-ketoglutarate (αKG) energy-generating anaplerotic flux to be critical in mitochondrial DNA (mtDNA) mutant cells that harbor human disease-associated oxidative ph...
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| Veröffentlicht in: | Cell Metab |
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| Hauptverfasser: | , , , , , , , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2018
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5932217/ https://ncbi.nlm.nih.gov/pubmed/29657030 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2018.03.002 |
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