Rewiring of glutamine metabolism is a bioenergetic adaptation of human cells with mitochondrial DNA mutations

Using molecular, biochemical, and untargeted stable isotope tracing approaches, we identify a previously unappreciated glutamine-derived α-ketoglutarate (αKG) energy-generating anaplerotic flux to be critical in mitochondrial DNA (mtDNA) mutant cells that harbor human disease-associated oxidative ph...

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Veröffentlicht in:Cell Metab
Hauptverfasser: Chen, Qiuying, Kirk, Kathryne, Shurubor, Yevgeniya I., Zhao, Dazhi, Arreguin, Andrea J., Shahi, Ifrah, Valsecchi, Federica, Primiano, Guido, Calder, Elizabeth L., Carelli, Valerio, Denton, Travis T., Beal, Flint M., Gross, Steven S., Manfredi, Giovanni, D’Aurelio, Marilena
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5932217/
https://ncbi.nlm.nih.gov/pubmed/29657030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2018.03.002
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