Rewiring of glutamine metabolism is a bioenergetic adaptation of human cells with mitochondrial DNA mutations

Using molecular, biochemical, and untargeted stable isotope tracing approaches, we identify a previously unappreciated glutamine-derived α-ketoglutarate (αKG) energy-generating anaplerotic flux to be critical in mitochondrial DNA (mtDNA) mutant cells that harbor human disease-associated oxidative ph...

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Udgivet i:Cell Metab
Main Authors: Chen, Qiuying, Kirk, Kathryne, Shurubor, Yevgeniya I., Zhao, Dazhi, Arreguin, Andrea J., Shahi, Ifrah, Valsecchi, Federica, Primiano, Guido, Calder, Elizabeth L., Carelli, Valerio, Denton, Travis T., Beal, Flint M., Gross, Steven S., Manfredi, Giovanni, D’Aurelio, Marilena
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5932217/
https://ncbi.nlm.nih.gov/pubmed/29657030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2018.03.002
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