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MYC through miR-17-92 Suppresses Specific Target Genes to Maintain Survival, Autonomous Proliferation and a Neoplastic State

The MYC oncogene regulates gene expression through multiple mechanisms and its overexpression culminates in tumorigenesis. MYC inactivation reverses turmorigenesis through the loss of hallmark features of cancer including autonomous proliferation and survival. Here we report that MYC via miR-17-92 m...

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Détails bibliographiques
Auteurs principaux: Li, Yulin, Choi, Peter S., Casey, Stephanie C., Dill, David L., Felsher, Dean W.
Format: Artigo
Langue:Inglês
Publié: 2014
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4191901/
https://ncbi.nlm.nih.gov/pubmed/25117713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2014.06.014
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