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Antiproliferative 4-(1,2,4-oxadiazol-5-yl)piperidine-1-carboxamides, a new tubulin inhibitor chemotype

We discovered a new chemical class of antiproliferative agents, 4-(1,2,4-oxadiazol-5-yl)piperidine-1-carboxamides. SAR-guided optimization of the two distinct terminal fragments yielded a compound with 120 nM potency in an antiproliferative assay. Biological activity profile studies (COMPARE analysi...

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Autori principali: Krasavin, Mikhail, Sosnov, Andrey V., Karapetian, Ruben, Konstantinov, Igor, Soldatkina, Olga, Godovykh, Elena, Zubkov, Fedor, Bai, Ruoli, Hamel, Ernest, Gakh, Andrei A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4191898/
https://ncbi.nlm.nih.gov/pubmed/25155551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2014.07.089
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