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Depletion of the Chromatin Looping Proteins CTCF and Cohesin Causes Chromatin Compaction: Insight into Chromatin Folding by Polymer Modelling

Folding of the chromosomal fibre in interphase nuclei is an important element in the regulation of gene expression. For instance, physical contacts between promoters and enhancers are a key element in cell-type–specific transcription. We know remarkably little about the principles that control chrom...

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Detalhes bibliográficos
Main Authors: Tark-Dame, Mariliis, Jerabek, Hansjoerg, Manders, Erik M. M., Heermann, Dieter W., van Driel, Roel
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4191888/
https://ncbi.nlm.nih.gov/pubmed/25299688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1003877
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