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Predicting the Functions and Specificity of Triterpenoid Synthases: A Mechanism-Based Multi-intermediate Docking Approach

Terpenoid synthases construct the carbon skeletons of tens of thousands of natural products. To predict functions and specificity of triterpenoid synthases, a mechanism-based, multi-intermediate docking approach is proposed. In addition to enzyme function prediction, other potential applications of...

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Detalhes bibliográficos
Main Authors: Tian, Bo-Xue, Wallrapp, Frank H., Holiday, Gemma L., Chow, Jeng-Yeong, Babbitt, Patricia C., Poulter, C. Dale, Jacobson, Matthew P.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4191879/
https://ncbi.nlm.nih.gov/pubmed/25299649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1003874
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